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If the chains successfully pair a pre-TCR types, and the cell downregulates CD25 and is termed a DN4 cell (CD25−CD44−). These cells then bear a round of proliferation, and start to re-arrange the TCRα ...
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ATR is said to a second checkpoint-activating kinase, ATM, which is activated by double strand breaks in DNA or chromatin disruption. ATR has additionally been proven to work on double strand breaks ( ...